CB1 – Cannabinoid Receptor Antagonist Effects on Cortisol in Cannabis-Dependent Men
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چکیده
منابع مشابه
Interaction between Antagonist of Cannabinoid Receptor and Antagonist of Adrenergic Receptor on Anxiety in Male Rat
Introduction: Anxiety is among the most common and treatable mental disorders. Adrenergic and cannabinoid systems have an important role in the neurobiology of anxiety. The elevated plus-maze (EPM) has broadly been used to investigate anxiolytic and anxiogenic compounds. The present study investigated the effects of intraperitoneal (IP) injection of cannabinoid CB1 receptor antagonist (AM251) i...
متن کاملCannabinoid Receptor 1 Gene by Cannabis Use Interaction on CB1 Receptor Density
Background: Because delta-9-tetrahydrocannabinol (THC), the primary psychoactive ingredient in cannabis, binds to cannabinoid 1 (CB1) receptors, levels of CB1 protein could serve as a potential biomarker for response to THC. To date, available techniques to characterize CB1 expression and function in vivo are limited. In this study, we developed an assay to quantify CB1 in lymphocytes to determ...
متن کاملCannabinoid CB1 Receptor-Dependent Long Term Depression in
25 Long term depression (LTD) of synaptic signaling—lasting from tens of minutes to hours 26 or longer—is a widespread form of synaptic plasticity in the brain. Neurons express 27 diverse forms of LTD, including autaptic LTD (autLTD) observed in cultured 28 hippocampal neurons, the mechanism of which remains unknown. We have recently 29 reported that autaptic neurons express both endocannabinoi...
متن کاملRimonabant, a selective cannabinoid CB1 receptor antagonist, inhibits atherosclerosis in LDL receptor-deficient mice.
OBJECTIVE The objective of this study was to determine whether the potent selective cannabinoid receptor-1 antagonist rimonabant has antiatherosclerotic properties. METHODS AND RESULTS Rimonabant (50 mg/kg/d in the diet) significantly reduced food intake (from 3.35+/-.04 to 2.80+/-0.03 g/d), weight gain (from 14.6+/-0.7 g to -0.6+/-0.3 g), serum total cholesterol (from 8.39+/-0.54 to 5.32+/-0...
متن کاملinteraction between antagonist of cannabinoid receptor and antagonist of adrenergic receptor on anxiety in male rat
introduction: anxiety is among the most common and treatable mental disorders. adrenergic and cannabinoid systems have an important role in the neurobiology of anxiety. the elevated plus-maze (epm) has broadly been used to investigate anxiolytic and anxiogenic compounds. the present study investigated the effects of intraperitoneal (ip) injection of cannabinoid cb1 receptor antagonist (am251) i...
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ژورنال
عنوان ژورنال: The American Journal of Drug and Alcohol Abuse
سال: 2011
ISSN: 0095-2990,1097-9891
DOI: 10.3109/00952990.2011.600398